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Considering our observation of strongly reduced MC migration on COL I, it seems plausible that COL I enrichment in vitiligo lesions interferes with the efficient MC redistribution into depigmented areas in the skin

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Before treatment: Avoid excessive sun exposure Stop retinol and exfoliating creams for 35 days Avoid waxing or aggressive facials Use sunscreen regularly Inform doctor about medications or skin treatments Melasma treatments are generally safe when performed by experienced specialists

Table 4 delineates the critical knowledge gaps and articulates specific, actionable research priorities essential for constructing a strategic roadmap to inform and guide future investigations in this domain

This includes good conditioning and technique, using proper equipment, and taking rest breaks